Efficacy of applet-based ACT focused on repetitive negative thinking for adults with comorbid anxiety and depression: A randomized controlled trial with mediation analysis

RCT (N=94) with a 14-day mobile intervention based on RNT-focused ACT for adults with elevated and comorbid anxiety and depression symptoms. Compared to waitlist, the program significantly reduced RNT, anxiety, and depression; changes were maintained at one month. Longitudinal analysis showed that RNT reduction mediated improvements in anxiety and depression. Evidence supports brief, digital transdiagnostic interventions.