ACTDepresiónAdultos mayores2026

Effect of a brief, focal ACT protocol to accelerate repetitive TMS with theta-burst stimulation for elderly patients with depression: A randomized, blinded, controlled trial

Authors

Bariani, B., Pinto, B. S., Santos, L. A., Benatti, R. G., Lessa, M. M. P., Loureiro, J. C., Silva, J. F., Silva, V. A., Cardeal, H. B., Pereira, J. L., Miranda, C. S., Forlenza, O. V., Leão, C. S., Ruiz, F. J., Brunoni, A. R., Valiengo, L.

Journal

Journal of Affective Disorders

Abstract

In older adults with MDD, we evaluated whether adding 4 ACT sessions to TBS (theta-burst rTMS) accelerates clinical response. In a double-blind, controlled RCT, ACT+TBS combination reduced depression (HDRS) faster at week 6 and showed higher remission than control with support sessions; differences did not persist at weeks 8–12. Integrating ACT could accelerate early TBS benefits in geriatric depression.

View full articleDOI: 10.1016/j.jad.2025.120182